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Interleukin-23 human
| 产品编号： | 4087137 |
| 规格： | IL-23, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture |
| 包装规格： | 5 μG，10 μG，5 X 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.77 |
| Quality【质量】 | endotoxin tested |
| General description【一般描述】 | HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like. Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3. |
| Biochem/physiol Actions【生化/生理作用】 | Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells. |
| Analysis Note【分析说明】 | The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC. |
| Legal Information【法律信息】 | HumanKine is a registered trademark of Proteintech Group, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | ≤2 ng/mL EC50 |
| mol wt【分子量】 | dimer 55 kDa (glycosylated) |
| packaging【包装】 | pkg of 5X10 μg pkg of 10 μg pkg of 5 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | ≤1EU/mg |
| UniProt accession no.【UniProt登记号】 | Q9NPF7 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL23A(51561) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
