Sodium Butyrate-CAS 156-54-7-Calbiochem

C₄H₇NaO₂

110.09

MFCD00002816

A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca²⁺ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells.
A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca²⁺ from intracellular stores. Downregulates the activity of serine/threonine protein kinase casein kinase II in HT29 cells.

Primary Target
Induce apoptosis
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Ou, H.C., et al. 1997. Neuroreport 8, 1375.
Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
Krupitza, G., et al. 1995. Carcinogenesis16, 1199.
Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun.195, 31.
Hague, A., et al. 1993. Int. J. Cancer55, 498.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

200

≥98% (titration)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

water: 2 mg/mL

ambient

−20℃

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

MFBOGIVSZKQAPD-UHFFFAOYSA-M

250 mg in Glass bottle

GHS05,GHS07

Danger

H302 - H314

P260 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

8A - Combustible, corrosive hazardous materials

WGK 1