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Calpeptin-CAS 117591-20-5-Calbiochem
| 产品编号： | 4087192 |
| 规格： | A cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). |
| CAS NO： | 117591-20-5 |
| 包装规格： | 5MG，25MG，100MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4087192 | 5MG | 1940 | |||
| 4087192 | 25MG | 4730 | |||
| 4087192 | 100MG | 13590 |
产品别名
117591-20-5
Calpeptin-CAS 117591-20-5-Calbiochem
Benzyloxycarbonylleucyl-norleucinal
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H30N2O4 |
| Molecular weight | 362.46 |
| MDL number | MFCD00155623 |
| General description【一般描述】 | A cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells. A cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Sequence【序列】 | Z-Leu-Nle-CHO |
| Preparation Note【制备说明】 | Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use. |
| Other Notes【其他说明】 | Lee, M.S., et al. 2000. Nature405, 360. Yamazaki, T., et al. 1997. Biochemistry27, 8377. Klafki, H., et al. 1996. J. Biol. Chem.271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun.153, 1201. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥94% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMF: 5 mg/mL DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1 |
| InChI key | PGGUOGKHUUUWAF-ROUUACIJSA-N |
| packaging【包装】 | Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
