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Bisdesethylchloroquine Hydrochloride
产品别名
Bisdesethylchloroquine Hydrochloride
Didesethylchloroquine hydrochloride
Bisdesethyl chloroquine hydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H18ClN3 · xHCl |
| Molecular weight | 263.77 (free base basis) |
| MDL number | MFCD00871854 |
| General description【一般描述】 | Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug. |
| Application【应用】 | Metabolomics research |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥95 % (HPLC) |
| form【形式】 | solid |
| storage temp.【储存温度】 | 2-8℃ |
