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Desethylchloroquine
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4087199 | 5 MG | 5060 | |||
| 4087199 | 25 MG | 10850 |
产品别名
1476-52-4
Desethylchloroquine
4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline
N-Desethyl chloroquine
N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine
7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline
7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline
Monodesethylchloroquine
N-Desethylchloroquine
Monodeethylchloroquine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H22ClN3 |
| Molecular weight | 291.82 |
| MDL number | MFCD00871808 |
| General description【一般描述】 | Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest. |
| Application【应用】 | Application: Metabolomics research |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | synthetic |
| grade【等级】 | research grade |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | powder or crystals |
| technique(s) | HPLC: suitable |
| color【颜色】 | white to off-white |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2 |
| InChI | 1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) |
| InChI key | MCYUUUTUAAGOOT-UHFFFAOYSA-N |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
