您的位置：首页 > 产品中心 > Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)
Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)
产品别名
Anti-IGF-IR (Ab-1) Mouse mAb (αIR3)
Anti-IGF-R, Anti-Insulin-Like Growth Factor Receptor
Anti-Insulin-Like Growth Factor Receptor, Anti-IGF-R
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | αIR3, monoclonal |
| form【形式】 | liquid |
| contains【包含】 | ≤0.1% sodium azide as preservative |
| species reactivity | human |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | do not freeze |
| isotype【同位素/亚型】 | IgG1 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 100 μg in Plastic ampoule Please refer to vial label for lot-specific concentration. |
基本信息
| General description【一般描述】 | This Anti-IGF-IR (Ab-1) Mouse mAb (αIR3) is validated for use in Immunoblotting, IF, IP, Neutralization Studies, Paraffin Sections for the detection of IGF-IR (Ab-1). Purified mouse monoclonal antibody generated by immunizing SJL mice with the specified immunogen and fusing splenocytes with FO mouse myeloma cells (see application references). Recognizes the ~130 kDa α and the ~90 kDa β subunits of IGF-I receptor. Recognizes the ~130 kDa α and the ~90 kDa β subunits of IGF-I receptor. |
| Immunogen【免疫原】 | partially purified, human placenta IGF-I receptor Human |
| Application【应用】 | Immunoblotting (not recommended) Immunofluorescence (1-5 µg/ml) Immunoprecipitation (1-2 µg/sample) Neutralization Studies (1 µg/ml; use Cat. No. GR11L) Paraffin Sections (not recommended) |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | In 0.05 M sodium phosphate buffer, 0.2% gelatin. |
| Analysis Note【分析说明】 | Positive Control HepG2 cells Negative Control HS27 cells |
| Other Notes【其他说明】 | Roth, R. 1988. Science239, 1269. Rohlik, Q.T., et al. 1987. Biochem. Biophy Res. Comm.149, 276. Rosen, O.M., 1987. Science257, 1452. Rechler, M.M. and Nissley, S.P., 1986. Hormone Res.24, 152. Ullrich, A., et al. 1986. EMBO J.5, 2503. Zapf, S. and Froesch, E.R., 1986. Hormone Res.24, 121. Humbel, R.E., 1984. I. Chemistry; in Li Hormonal proteins and peptides. Vol 12, Chap. 4 (Academic Press, New York). Kull, F.C., et al. 1983. J. Biol. Chem.258, 6561. Anti-IGF-I Receptor (Ab-1) Mouse mAb (αIR3) immunoprecipitates the α and β subunits of the IGF-I receptor. Blocks IGF-I binding to its receptor and may bind weakly to the insulin receptor. It also inhibits the growth of MCF-7 cells in culture suggesting the IGF-I receptor may be involved in autocrine regulation of cell growth (see application references). Antibody should be titrated for optimal results in indvidual systems. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
