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Anti-PDL-1 Antibody
| 产品编号： | 4087496 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PDL-1 Antibody
PDL-1 Antibody, PDL-1, Programmed cell death 1 ligand-1, programmed death ligand 1, PD-L1, B7-H1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Programmed cell death 1 ligand 1 (PDL-1) is a B7 related protein belonging to the BTN/MOG family. PDL-1 is essential for T-cell proliferation and production of IL10 and IFNG. PDL-1 reduces the secretion of IL-2 and IL-10 from memory T cells by inhibiting cell-mediated immune responses. PDL-1 may be involved in reducing allogenic CD4+ memory T-cell responses to endothelial cells. PDL-1 is highly expressed in heart, skeletal muscle, placenta, and lung and weakly expressed in thymus, spleen, kidney, and liver. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human PDL-1. |
| Application【应用】 | Anti-PDL-1 Antibody is a highly specific rabbit polyclonal antibody, that targets Programmed cell death 1 ligand 1 & has been tested in western blotting, IHC (Paraffin) & Immunofluorescence. Research Sub Category Apoptosis - Additional Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected PDL-1 in human heart tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PDL-1 in human heart tissue. Research Category Apoptosis & Cancer |
| Quality【质量】 | Evaluated by Western Blotting in Raji cell lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected PDL-1 in 15 µg of Raji cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Raji cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable (paraffin) western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q9NZQ7 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~30 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and 1 at ~33 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
