Anti-MRP2 antibody produced in rabbit

MFCD01865475

NA.41

Multidrug resistance associated protein 2 (MRP2) is expressed in endothelial cells of the blood-brain barrier, various carcinoma cell lines and tumors. The gene encoding MRP2 is localized on human chromosome 10q24 and consists of 32 exons.
Multidrug Resistance-associated Protein 2 (MRP2), also called as canalicular Multispecific Organic Anion Transporter (cMOAT), is a member of the CFTR/MRP (ABCC) subfamily of the large ATP-Binding Cassette (ABC) transporter family of transmembrane proteins. MRP2 is normally expressed in the liver, gallbladder, kidney proximal tubules, placenta, duodenum and small intestine. Localization pattern appears to vary in different species. MRP2 is predominantly localized to the apical membrane of polarized cells.

Additional lower bands including an approx. 175 kDa band representing an immature unglycosylated form may be detected in various extract preparations.

synthetic C-terminal peptide corresponding to amino acids 1528-1545 of human MRP2 conjugated to KLH.

Anti-MRP2 antibody produced in rabbit has been used in:

• immunoblotting
• western blotting
• immunofluorescence

Multidrug resistance associated protein 2 (MRP2) is a transporter which is involved in the efflux of various xenobiotic compounds like doxorubicin and methotrexate.
Multidrug Resistance-associated Protein 2 (MRP2) transports endogenous and exogenous anionic conjugates from hepatocytes to the bile. Thus, it contributes to bile flow and plays a role in detoxification and defense against oxidative stress. Patients with the rare autosomal recessive Dubin-Johnson Syndrome develop a mild liver disease caused by MRP2 deficiency. Up regulation of MRP2 expression may be found in hepatocellular carcinomas.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous solution

antigen ~190 kDa

human, rat

indirect immunofluorescence: 1:100 using paraformaldehyde-fixed HepG2 cells
indirect immunofluorescence: 1:100 using rat liver frozen sections
western blot: 1:1,000 using whole extract of HepG2 human hepatoblastoma cells

Q92887

dry ice

−20℃

human ... ABCC2(1244)
rat ... Abcc2(25303)

200 μL in glass bottle

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12 - Non Combustible Liquids

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