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Anti-Aromatase Antibody
| 产品编号： | 4087568 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Aromatase Antibody
Cytochrome P450 19A1, Aromatase, CYPXIX, Cytochrome P-450AROM, Estrogen synthase
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Human Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis. |
| Specificity【特异性】 | Other homolgoies: Rat and Mouse (94% sequence homology). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human Aromatase. |
| Application【应用】 | Anti-Aromatase Antibody is an antibody against Aromatase for use in WB. Western Blot Analysis: 1 µg/mL from a representative lot detected Aromatase in 10 µg of human testis. Research Sub Category Neurochemistry & Neurotrophins Research Category Neuroscience |
| Quality【质量】 | Evaluated by Western Blot in human placenta tissue lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Aromatase in 10 µg of human placenta tissue lysate. Tween was not used in the Western Blot. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Human placenta tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | pig, human |
| species reactivity (predicted by homology) | rhesus macaque (based on 100% sequence homology), porcine (based on 100% sequence homology), bovine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), canine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000094 |
| UniProt accession no.【UniProt登记号】 | P11511 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~58 kDa observed. UniProtKB/Swiss-Prot P11511 (CP19A_HUMAN) states a molecular weight of ~58 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
