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产品别名
Anti-GABPA Antibody
GA-binding protein alpha chain, GABP subunit alpha, GABPA
基本信息
| eCl@ss | 32160702 |
| General description【一般描述】 | GA-binding protein alpha chain (UniProt Q00422; also known as GA repeat binding protein alpha, GABP subunit alpha, GABPalpha, NRF-2, Nuclear respiratory factor-2) is encoded by the Gabpa gene (also known as E4tf1a) in murine species (Gene ID 14390). GABPalpha is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process. GABPalpha is upregulated in response to oxidant exposure or increased cellular reactive oxygen species (ROS), where it mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to mouse GABPA near the C-terminus. Epitope: Near C-terminus |
| Application【应用】 | Research Sub Category Nuclear Receptors Western Blotting Analysis: A representative lot detected GABPA in mouse liver nuclear proteins (Cherry, A.D., et al. (2014). J. Biol. Chem. 289(1):41-52). Chromatin Immunoprecipitation Analysis: A representative lot detected GABPA occupancy at the Sod2 promoter region by ChIP using liver chromatin preparation from mice after S. aureus inoculation (Cherry, A.D., et al. (2014). J. Biol. Chem. 289(1):41-52). Detect GABPA using this Anti-GABPA Antibody validated for use in Western Blotting and Chromatin Immunoprecipitation (ChIP). Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | Evaluated by Western Blotting in mouse liver tissue lysate. Western Blotting Analysis: 2.0 µg/mL of this antibody detected GABPA in 10 µg of mouse liver tissue lysate. |
| Physical form【外形】 | Format: Purified Protein A purified Purified rabbit polyclonal antibody in buffer containing PBS and 0.01% Sodium Azide. |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human, mouse, rat |
| species reactivity (predicted by homology) | canine (based on 100% sequence homology), monkey (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) | ChIP: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_032091 |
| UniProt accession no.【UniProt登记号】 | Q00422 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~55 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
