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Anti-IRGM Antibody
| 产品编号： | 4087724 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-IRGM Antibody
IRGM Antibody, Immunity related GTPase family, IFL1, IRGM1, LRG47, LRG-47
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Immunity-related GTPase family M protein (IRGM), also known as Interferon-inducible protein 1 (IFI1) and LPS-stimulated RAW 264.7 macrophage protein 47 homolog (LRG-47), is a member of the interferon-inducible GTPase family. It induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. IRGM is expressed in colon, small bowel, and peripheral blood leukocytes. Mutations in IRGM have been assoicated with inflammatory bowel disease type 19 which is subdivided into Crohn′s disease and ulcerative colitis phenotypes. |
| Specificity【特异性】 | This antibody recognizes the intermediate domain of IRGM. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the intermediate domain of human IRGM. |
| Application【应用】 | Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected IRGM in human brain tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IRGM in human brain cells. Detect Immunity-related GTPase family M protein using this rabbit polyclonal antibody, Anti-IRGM Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence. |
| Quality【质量】 | Evaluated by Western Blotting in human brain tissue lysate. Western Blotting Analysis: 2 µg/mL of this antibody detected IRGM in 15 µg of human brain tissue lysate. |
| Other Notes【其他说明】 | Antigen Affinity Purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable (paraffin) western blot: suitable |
| UniProt accession no.【UniProt登记号】 | A1A4Y4 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~31 kDa observed. Uncharacterized bands may appear in some lysates. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
