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Anti-SAPAP3 Antibody
| 产品编号： | 4087769 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-SAPAP3 Antibody
SAP90, PSD-95-associated protein 3, Disks large-associated protein 3, DLGAP3
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | SAP90/PSD-95-associated protein 3 (SAPAP3, also known as DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist. |
| Specificity【特异性】 | This antibody recognizes isoforms SAPAP3α and SAPAP3β. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human SAPAP3. |
| Application【应用】 | Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected SAPAP3 in mouse midbrain tissue. Research Category Neuroscience Research Sub Category Developmental Neuroscience This SAPAP3 antibody is validated for use in WB & IHC for the detection of the SAPAP3 protein. |
| Quality【质量】 | Evaluated by Western Blot in rat brain tissue lysate. Western Blot Analysis: 2 µg/mL of this antibody detected SAPAP3 in 15 µg/mL of rat brain tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Rat brain tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, rat |
| species reactivity (predicted by homology) | human (immunogen homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | O95886 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... DLGAP1(9229) |
产品说明
| Target description【目标描述】 | ~110/130 kDa observed. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
