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Anti-ACVR1B Antibody
| 产品编号： | 4087798 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ACVR1B Antibody
Activin A receptor type IB, Activin receptor-like kinase 4, Activin receptor type 1B precursor, ACTR-IB, ACVRLK4, ALK4, ALK-4, Serine/threonine-protein kinase receptor R2, SKR2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Activin receptor type-1B (ACVR1B) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. ACVR1B is known to form activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Within this receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors (including ACVR1B) act as downstream transducers of activin signals. Activins play role in many physiological and pathological processes including neuronal differentiation and neuronal survival, wound healing, extracellular matrix production, hair follicle development and cycling, FSH production, immunosuppression and carcinogenesis. ACVR1B is expressed highly in systemic sclerosis patient fibroblasts which suggests that the activin/ACRV1B signaling mechanism is involved in systemic sclerosis. ACVR1B is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the C-terminus of human ACVR1B. |
| Application【应用】 | Research Sub Category Pluripotent & Early Differentiation Anti-ACVR1B Antibody is a highly specific rabbit polyclonal antibody, that targets Activin receptor type-1 & has been tested in western blotting. Research Category Stem Cell Research |
| Quality【质量】 | Evaluated by Western Blotting/Peptide Inhibition Assay in human kidney tissue lysate. Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected ACVR1B in 15 µg human kidney tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Analysis Note【分析说明】 | Control Human kidney tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| UniProt accession no.【UniProt登记号】 | P36896 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... ACVR1B(91) |
产品说明
| Target description【目标描述】 | ~70 kDa observed. Uniprot describes 5 isoforms ranging between ~52 kDa and ~62 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
