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Anti-MACC1 Antibody

产品编号:4087842
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4087842100 μG5850
产品别名

Anti-MACC1 Antibody

Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5, MACC1

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Metastasis-associated in colon cancer protein 1, also known as SH3 domain-containing protein 7a5, and encoded by the gene name MACC1, is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway. This pathway is involved in cellular growth, epithelialmesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.
Immunogen【免疫原】
Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human MACC1.
Application【应用】
Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected MACC1 in human liver tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected MACC1 in human liver cells.
Research Category
Apoptosis & Cancer
Anti-MACC1 Antibody is an antibody against MACC1 for use in western blotting, IHC & immunofluorescence.
Quality【质量】
Evaluated by Western Blotting in Mouse liver tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected MACC1 in Mouse liver tissue lysate.
Physical form【外形】
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~93 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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