Anti-Substance P Receptor Antibody, pain

32160702

NA.41

Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapses. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.

Specific for the Substance P Receptor (NK-1).

Epitope: C terminus
Synthetic peptide that corresponds to a 23 amino acid sequence (385-407) of the COOH terminus of the rat Substance P Receptor (NK-1).

Research Sub Category
Neuroinflammation & Pain
Anti-Substance P Receptor Antibody, pain detects level of Substance P Receptor & has been published & validated for use in IF, IH & WB.
Immunohistochemistry:
A previous lot was used at 1:100-1:1,000 dilution.

Western Blot Analysis:
A previous lot was used at 1:500 dilution.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience

Evaluated by western blot on Mouse brain membrane lysates.

Western Blot Analysis:
1:500 dilution of this antibody detected NK-1R on 10 μg of Mouse brain membrane lysates.

Replaces: AB5800

Unpurified
Rabbit polyclonal serum containing no preservative.

Control
Spinal Cord, brain membrane lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

rabbit

100

serum

primary antibodies

polyclonal

mouse, rat, guinea pig

Chemicon^®

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

NM_003182.1

P20366

dry ice

human ... TAC1(6863)

35 kDa

Stable for 1 year at -20ºC from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

11 - Combustible Solids

WGK 1