Anti-STAT1 Antibody, CT

32160702

NA.41

STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway.

STAT 1, is activated by a number of different ligands, including IFNalpha, IFNgamma, EGF, PDGF and IL6. Phosphorylation of tyrosine 701 is required for STAT 1 dissociation from IFNGR1, homodimerization, and nuclear translocation. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions.

Recognizes STAT1.

GST fusion-protein containing the carboxy terminal 36 amino acids of human STAT1α

Detect STAT1 also known as Signal Transducer & Activator of Transcription 1 with Anti-STAT1 Antibody, CT (Rabbit Polyclonal Antibody), that has been demonstrated to work in EMSA, IP & WB.

routinely evaluated by immunoblot on RIPA lysates from human Jurkat cells, mouse CTLL or rat L6 cells

Protein A purified
Format: Purified

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

rabbit

100

purified antibody

primary antibodies

polyclonal

human, mouse

Upstate^®

electrophoretic mobility shift assay: suitable
immunoprecipitation (IP): suitable
western blot: suitable

IgG

NM_007315

P42224

wet ice

human ... STAT1(6772)

91 kDa

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12 - Non Combustible Liquids

WGK 1