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Anti-Androgen Receptor Antibody, Alexa Fluor® 647 Conjugate
产品别名
Anti-Androgen Receptor Antibody, Alexa Fluor® 647 Conjugate
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.45 |
| General description【一般描述】 | Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor. Epitope: This antibody recognizes the Modulating Region within the N-terminal of androgen receptor. |
| Application【应用】 | Research Sub Category Hormones & Receptors Detect Androgen Receptor using this Anti-Androgen Receptor Antibody, Alexa Fluor® 647 Conjugate validated for use in Immunocytochemistry. Research Category Epigenetics & Nuclear Function The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications. |
| Quality【质量】 | Evaluated by Immunocytochemistry in MCF-7 cells. Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Androgen Receptor in MCF-7 cells. |
| Physical form【外形】 | Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
| Legal Information【法律信息】 | ALEXA FLUOR is a registered trademark of Life Technologies |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | ALEXA FLUOR® 647 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human, rat |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology), horse (based on 100% sequence homology), canine (based on 100% sequence homology), mouse (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable |
| NCBI accession no.【NCBI登记号】 | NP_036634 |
| UniProt accession no.【UniProt登记号】 | P15207 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~110 kDa observed. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
