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Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor® 488 conjugate
产品别名
Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor® 488 conjugate
Cyclic AMP-responsive element-binding protein 1 (pSer133), cAMP-responsive element-binding protein 1 (pSer133), CREB-1 (pSer133), CREB-A (pSer133), htCREB (pSer133), CREB-B (pSer119)
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.45 |
| General description【一般描述】 | Cyclic AMP-responsive element-binding protein 1 (UniProt P16220; also known as cAMP-responsive element-binding protein 1, CREB-1) is encoded by the CREB1 gene (Gene ID 1385) in human. CREB is a transcription factor that binds the cAMP response elements (CRE) and regulates the transcription of the downstream genes. CREB activity is regulation via phosphorylation by various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases. Genes known to be regulated by CREB include c-fos, BDNF, tyrosine hydroxylase, neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone), as well as the circadian clock genes PER1 and PER2. CREB is critical for memory formation across a wide range of species. |
| Specificity【特异性】 | Recognizes phosphorylated CREB-A (pSer133), htCREB (pSer133), and CREB-B (pSer119) spliced isoforms reported by (UniProt P16220). May also recognize phosphorylated CREM and ATF-1 that contain homologous sequence to that of the immungen peptide. |
| Immunogen【免疫原】 | KLH-conjugated synthetic peptide corresponding to the amino acids including and encompassing phosphorylated Ser133 of CREB-A. Epitope: pSer133. |
| Application【应用】 | Anti-phospho-CREB (Ser133) Antibody, Alexa Fluor® 488 conjugate is an antibody against phospho-CREB for use in Immunofluorescence. Research Sub Category Transcription Factors The unconjugated antibody (Cat. No. 06-519) is shown to be suitable also for Electrophoretic Mobility Shift Assay (EMSA), immunohistochemistry, and Western blotting applications. Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | Evaluated by Immunofluorescence in rat brain tissue. Immunofluorescence Analysis: A 1:50 dilution of this antibody detected phospho-CREB (Ser133) in rat brain tissue. |
| Physical form【外形】 | Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
| Legal Information【法律信息】 | ALEXA FLUOR is a registered trademark of Life Technologies |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| conjugate【偶联物】 | ALEXA FLUOR® 647 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human, mouse, rat |
| species reactivity (predicted by homology) | Xenopus (based on 100% sequence homology), canine (based on 100% sequence homology), guinea pig (based on 100% sequence homology), chicken (based on 100% sequence homology), porcine (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) | immunofluorescence: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NP_604391 |
| UniProt accession no.【UniProt登记号】 | P16220 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... CREB1(1385) |
产品说明
| Target description【目标描述】 | ~43 kDa observed. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
