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Anti-CENP-A Antibody
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | CENP-A is a variant version of histone H3 found only at centromeres. Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker. |
| Specificity【特异性】 | CENP-A Broad species cross-reactivity is predicted. |
| Immunogen【免疫原】 | peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A |
| Application【应用】 | Anti-CENP-A Antibody is a Rabbit Polyclonal Antibody for detection of CENP-A also known as Centromere autoantigen A & has been tested in WB. Research Sub Category Cell Cycle, DNA Replication & Repair Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | routinely evaluated by immunoblot in acid extracted histones from HeLa cells |
| Linkage【联系】 | Replaces: 04-205 |
| Physical form【外形】 | Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide. ImmunoAffinity Purified |
| Analysis Note【分析说明】 | Control Control Histones (from Hela cells) colcemid-treated or untreated |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NM_001809 |
| UniProt accession no.【UniProt登记号】 | P49450 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 17kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2 to 8ºC from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
