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Anti-Cyclin E Antibody

产品编号:4088429
规格:Upstate®, from rabbit
包装规格:100 μg
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4088429100 μg5520
基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Specificity【特异性】
Cyclin E
Immunogen【免疫原】
KLH-conjugated, synthetic peptide corresponding to amino acids 378-396 (GVLTPPHSSKKQSSEQETE) of rat Cyclin E
Application【应用】
Research Sub Category
Cell Cycle, DNA Replication & Repair
Detect Cyclin E with Anti-Cyclin E Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB & IHC.
Research Category
Epigenetics & Nuclear Function
Quality【质量】
routinely evaluated by immunoblot on RIPA lysates from 3T3/A31 cells
Linkage【联系】
Replaces: 04-223
Physical form【外形】
ImmunoAffinity Purified
PBS containing 0.1% sodium azide and 0.2% gelatin.
Analysis Note【分析说明】
Control
3T3/A31 cell lysate, human colon carcinoma tissue
Legal Information【法律信息】
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
rat, mouse
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NM_001238.1
NM_057182.1
UniProt accession no.【UniProt登记号】
P24864
shipped in【运输】
wet ice
Gene Information
human ... CCNE1(898)
产品说明
Target description【目标描述】
Mr 52kDa
Storage and Stability【储存及稳定性】
stable for 1 year at 4°C from date of shipment
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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