Anti-Cyclin E Antibody

32160702

NA.41

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Cyclin E

KLH-conjugated, synthetic peptide corresponding to amino acids 378-396 (GVLTPPHSSKKQSSEQETE) of rat Cyclin E

Research Sub Category
Cell Cycle, DNA Replication & Repair
Detect Cyclin E with Anti-Cyclin E Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB & IHC.
Research Category
Epigenetics & Nuclear Function

routinely evaluated by immunoblot on RIPA lysates from 3T3/A31 cells

Replaces: 04-223

ImmunoAffinity Purified
PBS containing 0.1% sodium azide and 0.2% gelatin.

Control
3T3/A31 cell lysate, human colon carcinoma tissue

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

rabbit

100

affinity purified immunoglobulin

primary antibodies

polyclonal

affinity chromatography

rat, mouse

Upstate^®

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

IgG

NM_001238.1
NM_057182.1

P24864

wet ice

human ... CCNE1(898)

Mr 52kDa

stable for 1 year at 4°C from date of shipment

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 2