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Anti-phospho-JAK2 (Tyr317) Antibody
产品别名
Anti-phospho-JAK2 (Tyr317) Antibody
Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), tyrosine-protein kinase JAK2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | JAK2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. |
| Specificity【特异性】 | This antibody recognizes phosphorylated JAK2. |
| Immunogen【免疫原】 | KLH-conjugated recombinant protein selected from residues corresponding to Tyr317 of JAK2. Epitope: Tyr317 |
| Application【应用】 | Research Category Signaling Detect phospho-JAK2 (Tyr317) using this Anti-phospho-JAK2 (Tyr317) Antibody validated for use in WB. |
| Quality【质量】 | Evaluated by Western Blot in JAK2 IP lysate (see below). Western Blot Analysis: A 1:500 dilution of this antibody detected phospho-JAK2 (Tyr317) on JAK2 IP lysate. |
| Physical form【外形】 | Unpurified Rabbit serum with 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | serum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_004963.1 |
| UniProt accession no.【UniProt登记号】 | O60674 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 130 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
