Anti-cAMP Antibody

32160702

NA.41

Cyclic adenosine monophosphate or cAMP is an intracellular by-product of ATP by adenylene cyclase when G-protein Coupled Receptors (GPCR) bind various ligands on the cell surface. Cyclic AMP acts as a second messenger for signal transduction across the cell membrane and is a part of kinase activation. It regulates the effects of glucagon and adrenaline along with the movement of calcium ions through ion channels. Since it is affected directly by GPCR activation, cAMP is studied as a means to monitor GPCR in the discovery of therapeutic drugs.

Specific for cAMP with no cross reaction to other nucleotides at concentrations to 1 mM. Reactive with cAMP fixed in tissues or acetylated cAMP. Not reactive with free, non-acetylated, cAMP in RIA or EIA assays.

2′O-succinyl cyclic AMP conjugated to BSA

Anti-cAMP Antibody detects level of cAMP & has been published & validated for use in IH(P).
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Research Category
Signaling

Evaluated by Immunohistochemistry in rat hippocampus and cerebellum tissue.
Immunohistochemistry Analysis: 1:100 dilution of this lot detected cAMP in rat hippocampus and cerebellum tissue.

Replaces: MABN1026

Unpurified rabbit serum
Diluted serum presented as liquid in PBS containing no preservatives.

Control
Rat hippocampus and cerebellum tissue

rabbit

100

serum

primary antibodies

polyclonal

rat

all

immunohistochemistry: suitable (paraffin)

wet ice

Maintain at -20°C in undiluted aliquots from date of shipment. Avoid repeated freeze/thaw cycles.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 2