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Anti-Gβ5 Antibody

产品编号:4088620
规格:Upstate®, from rabbit
包装规格:100 μg
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4088620100 μg4840
基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
The Gβ5 (GNB5 guanine nucleotide binding protein (G protein), beta 5) is a G protein subunit present predominantly in the central nervous system. This protein appears to be expressed in two forms, one found in the brain of 39 kDa and one found in the retina of 44 kDa. It has also been found that Gβ5 associates tightly with RGS7, a member of the superfamily of negative regulators of G protein signaling. These complexes have been localized to most regions of the brain, whereas G1-4 exhibit no observable colocalization with RGS7, despite their widespread codistribution throughout similar neuronal networks. This antibody is specific for a peptide sequence within the D1 blade which is not found in Gβ1-4.
Specificity【特异性】
Recognizes D1 area of Gβ5.
Immunogen【免疫原】
Epitope: D1
Unique peptide sequence derived from the D1 blade of the Gβ5 protein.
Application【应用】
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
This Anti-Gβ5 Antibody is validated for use in WB for the detection of Gβ5.
Research Category
Signaling
Optimal working dilutions must be determined by end user.
Quality【质量】
Routinely evaluated by Western Blot on L6 lysates.

Western Blot Analysis: 1:500 dilution of this lot detected G protein Gbeta5 on 10 μg of L6 lysates.
Linkage【联系】
Replaces: AB4068
Physical form【外形】
Purified
Format: Purified
Purified rabbit polyclonal IgG in phosphate buffered saline with 0.08% sodium azide.
Analysis Note【分析说明】
Control
L6 Cell Lysate, plasma membranes from rat cerebrum.
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information【法律信息】
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
mouse, human, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype【同位素/亚型】
IgG
NCBI accession no.【NCBI登记号】
NM_006578.3
UniProt accession no.【UniProt登记号】
O14775
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
This protein appears to be expressed in two forms, one found in the brain of 39 kDa and one found in the retina of 44 kDa
Storage and Stability【储存及稳定性】
Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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