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产品别名
Anti-IRAK1 Antibody, CT
interleukin-1 receptor-associated kinase 1, Pelle homolog
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | IRAK1, also known as Interleukin-1 receptor associated kinase 1, belongs to the tyrosine kinase related (TKL) family and is involved with mRNA stabilization and activation of NF-kappa B. IRAK1 is located in all tissue as 2 isoforms, with 1 binding quickly and then degrading while isoform 2 is activated by kinase, resulting in a slower more sustained response to cytokines. Phosphorylation of IRAK1 leads to recruitment of the adapter protein PELI1. IRAK1 utilizes 2 pathways, the first one allows for mediation of IL-1 inflammatory responses when TRAF6 is bound, which activates NF-kappa B, thereby inhibiting I kappa B alpha. A second pathway does not involve TRAF6 and results in the stabilization of mRNA. |
| Specificity【特异性】 | This antibody recognizes the C-terminal region of IRAK1. |
| Immunogen【免疫原】 | KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of IRAK1. Epitope: C-terminus |
| Application【应用】 | This Anti-IRAK1 Antibody, C-terminus is validated for use in WB for the detection of IRAK1. Research Sub Category Immunological Signaling Research Category Inflammation & Immunology |
| Quality【质量】 | Evaluated by western blot in jurkat lysate. Western Blot Analysis: A 1:50-1:500 dilution of this antibody detected IRAK1 on jurkat lysate. |
| Physical form【外形】 | Format: Purified Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide. Protein G Purified |
| Analysis Note【分析说明】 | Control Jurkat lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001020413.1 |
| UniProt accession no.【UniProt登记号】 | P51617 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~77 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
