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Anti-JMJD4 (NT) Antibody

产品编号:4088637
规格:from rabbit
包装规格:100 μg
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4088637100 μg6690
产品别名

Anti-JMJD4 (NT) Antibody

JMJD, Jumonji domain-containing protein 4, jumonji domain containing 4

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that remove specific methyl marks from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
JMJD4 is a transcription factor that is a putative histone demethylase. It is highly expressed in lymphoid (spleen) and hemopoietic (bone marrow) tissues
Specificity【特异性】
This antibody recognizes the N-terminal region of human JMJD4.
Immunogen【免疫原】
Epitope: N-terminus
The immunogen was a KLH-conjugated synthetic peptide corresponding to the N-terminal region of human JMJD4.
Application【应用】
Research Sub Category
Histone Modifying Proteins

Chromatin Biology
Use Anti-JMJD4 (N-terminus) Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC, ELISA to detect JMJD4 (N-terminus) also known as Jumonji domain-containing protein 4.
Research Category
Epigenetics & Nuclear Function
ELISA:
This antibody was reported by an outside laboratory to be suitable for ELISA.

Immunocytochemistry:
HeLa and NIH/3T3 cells incubated with anti-JMJD4 (N-terminus) stained positively on nuclei.
Quality【质量】
Western Blot Analysis:
1:250 dilution of this antibody detected JMJD4 on 10 µg of A431 lysate
Physical form【外形】
Protein G Chromatography
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Format: Purified
Analysis Note【分析说明】
Control
A431 lysate
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
species reactivity
mouse, human
technique(s)
ELISA: suitable
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_075383.1
UniProt accession no.【UniProt登记号】
Q9H9V9
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~53 kDa
Storage and Stability【储存及稳定性】
Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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