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Fmoc-Sec(pMeOBzl)-OH

产品编号:4089645
规格:Novabiochem®
CAS NO:150308-80-8
包装规格:250 MG,1 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4089645250 MG3930
40896451 G11770
产品别名

150308-80-8

Fmoc-Sec(pMeOBzl)-OH

Fmoc-Sec(Mob)-OH,Fmoc-S-4-methoxybenzyl selenocysteine

基本信息
Empirical Formula【经验(实验)分子式】
C26H25NO5Se
Molecular weight
510.44
General description【一般描述】
Building block for the introduction of selenocysteine during Fmoc SPPS [1-3]. Selenocysteine derivatives can undergo enantiomerization during coupling and can form dehydroalanine and β-piperidinylalanine containing side products during subsequent chain elongation [3]. Therefore, activation methods, such as HBTU or PyBOP which involve the addition of a tertiary, base should be avoided for addtion of the Sec and all subsequent residues.



Cleavage and side-chain deprotection of Sec-containing peptides can be effected using tFA-m-cresol-thioanisole-EDT-water (80:5:5:5:5)[2] or TFA-water-DCM-TIS (89:5:51) at 4 °C [3]. As the Se-pMeOBzl bond is stable to TFA, these emthods result in formation of the corresponding Sev(pMeOBzl) peptide.



Peptides containing two Sec(pMeOBzl) residues can be oxidized directly to the corresponding selenocystinyl peptides by treatment with 5-10% DMSO in TFA [1-3].
Analysis Note【分析说明】
Color (visual): white to yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(157A)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
For TLC-Systems see our General Catalog
Legal Information【法律信息】
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
200
product line【产品线】
Novabiochem®
Assay【测定】
≥98% (TLC)
≥98.0% (HPLC)
form【形式】
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
functional group【官能团】
Fmoc
storage temp.【储存温度】
2-8℃
安全信息
Pictograms【象形图】
GHS06,GHS08,GHS09
Signal word【警示用语:】
Danger
Hazard Statements
H301 + H331 - H315 - H335 - H373 - H410
Precautionary Statements
P260 - P273 - P301 + P310 - P302 + P352 - P304 + P340 + P311 - P314
Hazard Classifications【危险分类】
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
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