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Anti-ATF6 Antibody
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | ATF6 (Activating Transcription Factor 6, Cyclic AMP-dependent transcription factor ATF6) is a stress activated leucine zipper transcription factor involved in activating transcription of endoplasmic reticulum (ER) molecules in response to accumulation of unfolded proteins in the ER. ATF6 is originally a 90 kDa type II transmembrane glycoprotein that is converted to a 50 kDa soluble nuclear form, retaining its N-terminal domain, including the leucine zipper. Unfolded protein accumulation in the ER results in the cleavage of ATF6 to release its cytoplasmic domain that then enters the nucleus. ATF6 binds to an element designated ER Stress Response Element (ERSA) that appears in the promoter of glucose-regulated proteins (GRPs) such as GRP78, GPR94, and calreticulin. |
| Immunogen【免疫原】 | KLH-tagged synthestic peptide synthesized to the N-terminal region of human ATF6 designated as the Cytoplasmic Domain. |
| Application【应用】 | Research Category Signaling Epigenetics & Nuclear Function Research Sub Category Transcription Factors Detect ATF6 using this Anti-ATF6 Antibody validated for use in WB. |
| Quality【质量】 | Routinely evaluated by western blot on HeLa lysate. |
| Physical form【外形】 | Affinity purified Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide. |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Legal Information【法律信息】 | UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NP_031374 |
| UniProt accession no.【UniProt登记号】 | P18850 |
| shipped in【运输】 | dry ice |
| Gene Information | human ... ATF6(22926) |
产品说明
| Target description【目标描述】 | 90 kDa |
| Storage and Stability【储存及稳定性】 | 1 year at -20°C |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
