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Anti-Dock2 Antibody
| 产品编号： | 4090200 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μg |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Dock2 Antibody
dedicator of cyto-kinesis 2, dedicator of cytokinesis 2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Dock2 (Dedicator of cytokinesis 2), is a large protein involved in intracellular signaling networks and a member of the DOCK-A subfamily which function as activators of small G proteins. Dock2 specifically activates isoforms of the small G protein Rac and appears to be expressed specifically in leukocytes. These cells express both Rac1 and Rac2 and Dock2 has been shown to bind and promote nucleotide exchange on both of these isoforms. (Nishihara, 1999) |
| Specificity【特异性】 | 09-454 recognizes mouse DOCK2. Predicted to cross react with human, equine, and primate, based on 93% sequence homology (13/14 aa). The sequence is 85.7% homologous in rat. Reactivity with other species has not been tested. |
| Immunogen【免疫原】 | Epitope: Internal region KLH-conjugated synthetic peptide near amino acid 1730, within the internal region of mouse DOCK2. |
| Application【应用】 | Research Category Cell Structure Western Blotting; Anti-Dock2 Antibody is an antibody against Dock2 for use in WB Immunohistchemistry (Frozen sections): A representative lot of this antibody dectected DOCK2 in mouse and human brain frozen tissue sections (Cimino, PJ et al. (2009). Am. J. Pathol. 175(4); 1622-1630) Research Sub Category Cytoskeleton |
| Quality【质量】 | Evaluated by Western blot on mouse spleen lysate 0.5 μg/mL of Anti-DOCK2 at 1 mg/mL. |
| Physical form【外形】 | Purified in PBS containing 0.05% NaN3. Peptide affinity purified |
| Analysis Note【分析说明】 | Control Mouse spleen lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | primate, mouse, horse, human |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG |
| NCBI accession no.【NCBI登记号】 | NM_004946.2 |
| UniProt accession no.【UniProt登记号】 | Q8C3J5 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 180 kDa |
| Storage and Stability【储存及稳定性】 | Maintain at 2-8°C for up to 1 year from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
