ODQ-CAS 41443-28-1-Calbiochem

C₉H₅N₃O₂

187.15

MFCD00792620

A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ fails to inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀ = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.

Cell permeable: yes
Primary Target
(NO)-sensitive guanylyl cyclase
Product does not compete with ATP.
Target IC₅₀: 20 nM against nitric oxide (NO)-sensitive guanylyl cyclase
Reversible: yes

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Wang, D., et al. 1998. J. Biol. Chem. 273, 33027.
Southam, E., et al. 1996. Br. J. Pharmacol. 119, 527.
Brunner, F., et al. 1995. FEBS Lett.376, 262.
Garthwaite, J., et al. 1995. Mol. Pharmacol.48, 184.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (TLC and HPLC)

powder

Calbiochem^®

OK to freeze
protect from light

light yellow

DMSO: 25 mg/mL

ambient

−20℃

1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

LZMHWZHOZLVYDL-UHFFFAOYSA-N

10 mg in Plastic ampoule

11 - Combustible Solids

WGK 3