Antipain, Dihydrochloride-CAS 37682-72-7-Calbiochem

C₂₇H₄₄N₁₀O₆ · 2HCl

677.62

MFCD00135957

Effective concentration: 1-100 µM.
A reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC₅₀ = 300 µM).

Target IC₅₀: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM
Product does not compete with ATP.
Cell permeable: no
Reversible: yes
Primary Target
trypsin-like serine proteases, papain, and some cysteine proteases

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385
Umezawa, H. 1976. Methods Enzymol.55, 678.
Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

powder

Calbiochem^®

OK to freeze
desiccated (hygroscopic)
protect from light

white

water: 1 mg/mL
DMSO: 5 mg/mL

ambient

2-8℃

1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1

GXQPAKIVOCLCHD-BXLPLHKWSA-N

10 mg in Plastic ampoule

11 - Combustible Solids

WGK 3