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Caspase 10 human
| 产品编号： | 4091381 |
| 规格： | >90% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, 8,000 units/mg protein (Bradford) |
| 包装规格： | 25 UNITS，100 UNITS |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Caspase 10 human
Flice2
Mch4
基本信息
| MDL number | MFCD03456342 |
| NACRES | NA.32 |
| Biochem/physiol Actions【生化/生理作用】 | Caspase 10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase 10 cleaves and activates caspases 3, 4, 6, 7, 8 and 9 which causes the proteolytic cleavage of many key proteins such as PARP. Based on gene expression studies, caspase 10 may be crucial in embryonic development. In view of its structural homology to caspase 8, the initiator caspase in death receptor-mediated apoptosis, caspase 10 may function in a similar and redundant manner. |
| Unit Definition【单位定义】 | One unit will hydrolyze 1 nmol of the caspase substrate IETD-pNA to IETD and p-nitroaniline per hour at pH 7.2 at 37 ℃. |
| Physical form【外形】 | Lyophilized powder containing 0.052% ammonium sulfate, 0.158% Tris−HCl, and 0.76% sodium chloride. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | >90% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| Specific Activity | 8,000 units/mg protein (Bradford) |
| mol wt【分子量】 | ~30 kDa |
| solubility【溶解性】 | PBS: soluble |
| UniProt accession no.【UniProt登记号】 | Q92851 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... CASP10(843) |
| packaging【包装】 | 25, 100 units in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
