您的位置：首页 > 产品中心 > Anti-phospho-α-B Crystallin (54-64) (pSer59) antibody produced in rabbit
Anti-phospho-α-B Crystallin (54-64) (pSer59) antibody produced in rabbit
| 产品编号： | 4091492 |
| 规格： | affinity isolated antibody, lyophilized powder |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD06798481 |
| NACRES | NA.41 |
| General description【一般描述】 | α-B-crystallin (CRYAB) belongs to small heat-shock protein family with chaperone-like function. Almost entire lens proteins composed of crystallins and within that α-crystallin accounts for 40% of total lens protein. α-Crystallin is composed of two primary gene products, α-A and α-B. α-B crystallin in particular, has been detected in many tissues in the central nervous system, and is considered to be a useful marker in a variety of neurodegenerative diseases. |
| Specificity【特异性】 | This antibody does not detect the unphosphorylated form of the protein. |
| Immunogen【免疫原】 | synthetic phosphopeptide: FLRAPS(p)WIDTG |
| Application【应用】 | Anti-phospho-α-B Crystallin (54-64) (pSer59) antibody is suitable for indirect immunofluorescence in 8μg/mL using human brain from Alexander′s diseased patients. It is also suitable for western blot analysis in concentration of 0.5μg/mL using recombinant bovine phospho-α-B crystallin (Ser59). |
| Biochem/physiol Actions【生化/生理作用】 | Anti-phospho-α-B Crystallin (54-64) (pSer59) antibody is responsible for the optical properties of the lens and have been identified from metabolic enzymes and stress proteins. In many neurological diseases, α B-crystallin have found over-expressed and any alterations in this protein leads cataract and myopathy. In addition to maintaining proper refractive index, it also functions in a chaperone-like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of α-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance. |
| Physical form【外形】 | Lyophilized from phosphate buffered saline, pH 7.4, with 3% bovine serum albumin and 0.05% sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | lyophilized powder |
| species reactivity | rat, human, bovine |
| technique(s) | indirect immunofluorescence: 8 μg/mL using human brain from Alexander′s diseased patients western blot: 0.5 μg/mL using recombinant bovine phospho-α-B crystallin (Ser59) |
| UniProt accession no.【UniProt登记号】 | P02511 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CRYAB(1410) rat ... Cryab(25420) |
