Coelenterazine-CAS 122384-88-7-Calbiochem

C₂₆H₂₁N₃O₃

423.46

MFCD00467176

Coelenterazine (CTZ), a small prosthetic group, is a luciferin or light-producing compound present in luminous marine organisms. The imidazopyrazinone ring in CTZ is responsible for its luminous properties. This chemiluminescent dye is soluble in methanol and poorly soluble in water. CTZ can be oxidized with the help of bovine serum albumin (BSA) and several other luciferases.

Coelenterazine - CAS 122384-88-7 – Calbiochem may be used:

• to determine superoxide production
• to determine free radical production
• in cell suspension buffer for in vivo reconstitution of aequorin

Coelenterazine (CTZ) is a cell-permeable aequorin luminophore that acts as a very sensitive and specific chemiluminescence probe of the superoxide anion. It can also be used for detecting changes in intracellular Ca²⁺ in cells that have been transfected with apoaequorin cDNA. CTZ functions as a powerful antioxidant. It serves as a substrate for multidrug resistance protein 1 (MDR1) P-glycoprotein (ATP-binding cassette sub-family B member 1 (ABCB1)/Pgp) and can bind with apoaequorin to form the active aequorin complex. It can be mainly used to quantify the formation of superoxide in neutrophils.

Toxicity: Standard Handling (A)

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥90% (TLC)

solid

Calbiochem^®

OK to freeze
protect from light

brown

methanol: 1 mg/mL
ethanol: soluble

ambient

−20℃

1S/C26H21N3O3/c30-20-10-6-18(7-11-20)15-23-26(32)29-16-24(19-8-12-21(31)13-9-19)27-22(25(29)28-23)14-17-4-2-1-3-5-17/h1-13,16,27,30-31H,14-15H2

YHIPILPTUVMWQT-UHFFFAOYSA-N

250 μg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1