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Proteinase 3 from human leukocytes
产品别名
Proteinase 3 from human leukocytes
Myeloblastin
PR3 Ag
PR-3
P29B
AGP7
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 3.4.21.76 ( BRENDA | IUBMB ) |
| MDL number | MFCD03458212 |
| NACRES | NA.54 |
| General description【一般描述】 | Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.4 |
| Application【应用】 | Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.1 It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.2 |
| Biochem/physiol Actions【生化/生理作用】 | Used for the detection of anti-PR3 auto-antibodies in immunoassays. Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.3 |
| Physical form【外形】 | Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥95% (PAGE) |
| form【形式】 | buffered aqueous solution |
| UniProt accession no.【UniProt登记号】 | P24158 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PRTN3(5657) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
