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Etoposide-CAS 33419-42-0-Calbiochem
| 产品编号： | 4092492 |
| 规格： | A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 μM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lympho |
| CAS NO： | 33419-42-0 |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4092492 | 25 MG | 1040 |
产品别名
33419-42-0
Etoposide-CAS 33419-42-0-Calbiochem
VP-16
基本信息
| Empirical Formula【经验(实验)分子式】 | C29H32O13 |
| Molecular weight | 588.56 |
| MDL number | MFCD00869325 |
| General description【一般描述】 | A cell-permeable, topoisomerase II inhibitor (IC50 = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells. A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC50 = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Target IC50: 59.2 µM inhibiting topoisomerase II Primary Target topoisomerase 2 |
| Warning【警告】 | Toxicity: Harmful & Carcinogenic / Teratogenic (E) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | De Lange, A.M., et al. 1995. J. Virol. 69, 2082. Kaufman, S.H., et al. 1993. Cancer Res.53, 3976. Onishi, Y., et al. 1993. Biochim. Biophys. Acta1175, 147. Terada, T., et al. 1993. J. Med. Chem. 36, 1689. Wazniak, A.J., et al. 1991. J. Clin. Oncol.9, 70. Einhorn, L.H., et al. 1988. J. Clin. Oncol.6, 451. Issel, B.F. 1982. Cancer Chemother. Pharmacol.7, 73. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1 |
| InChI key | VJJPUSNTGOMMGY-MRVIYFEKSA-N |
| packaging【包装】 | 25 mg in Plastic ampoule |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H350 - H361d - H412 |
| Precautionary Statements | P201 - P202 - P264 - P273 - P301 + P312 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 1B - Repr. 2 |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
