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Fractalkine, Chemokine Domain from mouse
| 产品编号： | 4092522 |
| 规格： | >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder |
| 包装规格： | 25 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Fractalkine, Chemokine Domain from mouse
CX3CL-1
Neurotactin
基本信息
| MDL number | MFCD01635336 |
| NACRES | NA.32 |
| General description【一般描述】 | CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons. |
| Biochem/physiol Actions【生化/生理作用】 | CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease. In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD. Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX3C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin. |
| Analysis Note【分析说明】 | The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | >97% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | 0.3-3 μg/mL |
| mol wt【分子量】 | calculated mol wt ~9.5 kDa |
| packaging【包装】 | pkg of 25 μg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| impurities【杂质】 | endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | O35188 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Cx3cl1(20312) |
安全信息
| Pictograms【象形图】 | GHS05 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H315 - H318 |
| Precautionary Statements | P280 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Dam. 1 - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
