FLT1 (784-end), active, GST tagged human

NA.32

FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is one of the receptor tyrosine kinase, which acts as a receptor for VEGF. VEGF is a predominant angiogenesis stimulating factor. FLT1 is a transmembrane receptor. Soluble FLT1 (sFLT1) is an alternatively spliced soluble form of FLT1, expressed by multiple tissues. It acts as a negative regulator of VEGF. It does not contain the cytosolic and transmembrane domains.

FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is implicated in angiogenesis in tumors, which plays a key role in tumorigenesis, invasion and metastasis of tumors, especially the malignant ones. In human circulation, angiogenesis is balanced by soluble FLT1 (sFLT1) and VEGF. An imbalance leads to multiple conditions such as pre-eclampsia. sFLT1 plays an essential role in the angiogenesis of placenta. An overexpression of this protein in placenta is associated with prenatal arsenic exposure and thus, reduced birth weight.

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

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200

expressed in baculovirus infected Sf9 cells

PRECISIO^® Kinase

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

30-40 nmol/min·mg

~94 kDa

P17948

dry ice

−70℃

human ... FLT1(2321)

10 - Combustible liquids

WGK 1