Follistatin 288 from mouse

MFCD03456879

NA.32

FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.

FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.
High affinity activin-binding protein that can act as an activin antagonist.

Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.

The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.

100

mouse

expressed in baculovirus infected Sf21 cells

>95% (SDS-PAGE)

lyophilized powder

0.04-0.4 mg per mL

calculated mol wt ~31 kDa

avoid repeated freeze/thaw cycles

endotoxin, tested

P47931

−20℃

mouse ... Fst(14313)

25 μg in glass insert

GHS05

Danger

H315 - H318

P280 - P305 + P351 + P338 + P310

Eye Dam. 1 - Skin Irrit. 2

13 - Non Combustible Solids

WGK 3