FYN A, active, GST tagged human

NA.32

FYN proto-oncogene is a member of the Src family of tyrosine kinases, and has a molecular weight of 59kDa. Post-synthesis this protein is N-myristoylated on cytoplasmic polysomes. It is palmitoylated after it has been targeted to the cell membrane. This protein can also be acylated twice, which leads to its clustering into microdomains in the caveolae-like membrane.

FYN proto-oncogene interacts with multiple signaling molecules, and is involved in T-cell receptor (TCR) signaling, brain function control, along with the control of adhesion-mediated signaling. It might have potential as a target for autoimmune disorders and alcohol addiction. It is also implicated in melanoma tumorigenes in a immunoglobulin (Ig)E-mediated manner. In mesenchymal stem cells, it controls RhoA and adipogenesis, through its interaction with mTORC2 (mammalian target of rapamycin complex 2).

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

200

expressed in baculovirus infected Sf9 cells

PRECISIO^® Kinase

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

141-195 nmol/min·mg

~85 kDa

P06241

dry ice

−70℃

human ... FYN(2534)

10 - Combustible liquids

WGK 1