Milli-Mark^® Anti-pan Histone-FITC Antibody, clone H11-4

32160702

NA.41

There are 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. The five major classes of histones are H1/H5, H2A, H2B, H3, and H4. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones. Histones feature a main globular domain and a long N terminal tail which are involved with the structure of the nucleosomes of the ′beads on a string′ structure. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation.

Due to the highly conserved nature of histones, this antibody is predicted to have wide species reactivity.

This Milli-Mark Anti-pan Histone-FITC Antibody, clone H11-4 is validated for use in FC for the detection of pan Histone.

Evaluated by flow cytometry using HeLa cells.

Protein A purified

100

mouse

FITC conjugate

purified immunoglobulin

primary antibodies

H11-4, monoclonal

human

Milli-Mark^®

flow cytometry: suitable

IgG1

wet ice

Antibody recognizes histones H1, H2A, H2B, H3, and H4. Calculated molecular weight for these histones range from 14 to 21 kDa

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10 - Combustible liquids

WGK 2