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Pefloxacin 甲磺酸酯 二水合物
Pefloxacin mesylate dihydrate
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4092918 | 10 G | 505 |
产品别名
149676-40-4
Pefloxacin 甲磺酸酯 二水合物
Pefloxacin mesylate dihydrate
Pefloxacinium methanesulfonate dihydrate
Pefloxacine monomethanesulfonate dihydrate
3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate
结构式
基本信息
| Linear Formula【线性分子式】 | C17H20FN3O3 • CH4O3S • 2H2O |
| Molecular weight | 465.49 |
| EC number【EC 号】 | 274-613-9 |
| MDL number | MFCD01685696 |
| PubChem Substance ID【PubChem化学物质编号】 | 329820015 |
| General description【一般描述】 | Chemical structure: fluoroquinolone |
| Application【应用】 | Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes. |
| Biochem/physiol Actions【生化/生理作用】 | Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin. |
| Other Notes【其他说明】 | Keep container tightly closed in a dry and well-ventilated place. |
产品性质
| Quality Level【质量水平】 | 100 |
| solubility【溶解性】 | H2O: 50 mg/mL |
| Mode of action【作用机制】 | DNA synthesis | interferes enzyme | inhibits |
| antibiotic activity spectrum【抗生素抗菌谱】 | Gram-negative bacteria Gram-positive bacteria |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3 |
| InChI | 1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2 |
| InChI key | LEULAXMUNMRLPW-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 g in poly bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
