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Indomethacin-CAS 53-86-1-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4093783 | 10 G | 2150 |
产品别名
53-86-1
Indomethacin-CAS 53-86-1-Calbiochem
1-( p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H16ClNO4 |
| Molecular weight | 357.79 |
| MDL number | MFCD00057095 |
| General description【一般描述】 | A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells. A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50 = 740 nM for COX-1; IC50 = 970 nM for COX-2). Inhibits phospholipase A2 (IC50 = 145 µM). Reported to reduce Aβ42 levels independently of COX activity. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I) |
| Other Notes【其他说明】 | Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun.281, 483. Weggen, S., et al. 2001. Nature414, 212. Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 925. Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312. Futaki, N., et al. 1994. Prostaglandins47, 55. Futaki, N., et al. 1994. Prostaglandins47, 55. Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257. Oliw, E. 1980. Prostaglandins19, 271. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (by assay) |
| form【形式】 | powder |
| potency【效能】 | 740 nM IC50 |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | ethanol: 20 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) |
| InChI key | CGIGDMFJXJATDK-UHFFFAOYSA-N |
| packaging【包装】 | 10 g in Alu drum |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 1 Oral |
| Storage Class Code【储存分类代码】 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
