您的位置：首页 > 产品中心 > Macrophage Colony-Stimulating Factor human
Macrophage Colony-Stimulating Factor human
| 产品编号： | 4093842 |
| 规格： | M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Macrophage Colony-Stimulating Factor human
MCSF
基本信息
| MDL number | MFCD00166591 |
| NACRES | NA.77 |
| Quality【质量】 | endotoxin tested |
| General description【一般描述】 | M-CSF is encoded by the gene mapped to human chromosome 1p13.3. It is a glycosylated polypeptide, which exists as a homodimer. M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells. |
| Biochem/physiol Actions【生化/生理作用】 | Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells. It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages. In addition, human M-CSF inhibits bone resorption by osteoclasts. It might also play a crucial role in atherosclerosis. Overexpression of the gene has been observed in Paget′s disease of bone (PDB). |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution of 1x PBS. |
| Analysis Note【分析说明】 | The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line). |
| Citation【引用】 | 1. Mazur, E.M., and Cohen, J.L., Clin. Pharmacol. Ther., 46, 250 (1989). 2. Morstyn, G., and Burgess, A.W., Cancer Res., 48, 5624 (1988). 3. Metcalf, D., Blood, 67, 257 (1986). 4. Mufson, R.A., et al., Cell. Immunol., 119, 182 (1989). 5. Hattersley, G., et al., J. Cell Physiol., 137, 199 (1988). |
| Legal Information【法律信息】 | HumanKine is a registered trademark of Proteintech Group, Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | ≤4 ng/mL EC50 |
| mol wt【分子量】 | dimer 35-40 kDa (glycosylated) |
| manufacturer/tradename | HumanZyme |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no.【UniProt登记号】 | P09603 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... CSF1(1435) |
| packaging【包装】 | 10 μg in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
