Anti-Atrial Natriuretic peptide

32160702

NA.41

Natriuretic peptides A (UniProt: P01161; also known as CDD-ANF, ANP, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, Prepronatriodilatin) is encoded by the Nppa gene (Gene ID: 24062) in rat. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) are belong to the natriuretic peptide family. They are responsible for body fluid homeostasis and regulation of blood pressure. ANP is produced mainly by cardiac myocytes and is released in response to atrial stretch. Once in the circulation, ANP induces natriuresis, diuresis, and cause a reduction in blood pressure. In renal tissue ANP acts on receptors that increase glomerular filtration rate, reduce sodium reabsorption in the distal nephron, and diminish renin secretion. ANP has an intra-molecular ring structure connected by two cysteine residues and N-terminal and C-terminal extensions from it. ANP is produced with a signal peptide (aa 1-24) and a propeptide region (aa 25-122), which are cleaved to produce active hormone. It is cleaved by Corin by cleavage of Arg-Ser (aa 122-123) peptide bond. It can also be cleaved by membrane metalloendopeptidase between aa 129-130 that initiates its degradation and thereby regulate its activity.

This rabbit polyclonal antibody detects Natriuretic peptides A in rat and murine heart. It targets an epitope within 28 amino acids from the C-terminal region.

KLH-conjugated linear peptide corresponding to 28 amino acids from the C-terminal region of rat Natriuretic peptides A.

Epitope: C-terminus

Anti-Atrial Natriuretic peptide, Cat. No. AB5490-I, is a highly specific rabbit polyclonal antibody, that targets Natriuretic peptides A and has been tested in Western Blotting and Immunohistochemistry (Paraffin).
Research Category
Neuroscience
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Atrial Natriuretic peptide in rat heart and mouse heart tissue sections.

Evaluated by Western Blotting in rat heart tissue lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Atrial Natriuretic peptide in rat heart tissue lysate

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Affinity Purified

Concentration: Please refer to lot specific datasheet.

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

rabbit

affinity isolated antibody

primary antibodies

polyclonal

affinity chromatography

rat, mouse

antibody small pack of 25 μL

Chemicon^®

immunohistochemistry: suitable (paraffin)
western blot: suitable

NP_006163.1

P01161

~17 kDa observed; 16.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Stable for 1 year at 2-8°C from date of receipt.

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