Anti-mGluR2 Antibody

32160702

NA.41

The metabotropic glutamate receptors belong to a family of G protein-coupled receptors that have been divided into 3 groups based on their sequence homology, putative signal transduction mechanisms, and pharmacologic properties. mGluR2 belongs to the Group II. It is widely expressed in different regions of fetal and the adult brain. Ligand binding to GluR2 induces a conformation change in the receptor, which triggers signaling to modulate the activity of down-stream effectors, mainly via the inhibition of adenylate cyclase activity. Activation of mGluR2 leads to inhibition of glutamate release at the synaptic junction

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of mouse mGlur2.
Epitope: Cytoplasmic domain

Anti-mGluR2 Antibody is an antibody against mGluR2 for use in Western Blotting, Immunoprecipitation.
Research Category
Neuroscience
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated mGlur2 in 500 µg of rat brain microsomal prep.
Research Sub Category
Developmental Signaling

Evaluated by Western Blotting in rat brain microsomal prep.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected mGlur2 in 10 µg of rat brain microsomal prep.

Replaces: 07-261

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

Concentration: Please refer to lot specific datasheet.

rabbit

100

affinity isolated antibody

primary antibodies

polyclonal

affinity chromatography

rat

mouse (based on 100% sequence homology)

immunoprecipitation (IP): suitable
western blot: suitable

NP_001153825

Q14BI2

wet ice

~95/200 kDa observed. The lower band corresponds to the calculated molecular weight of mGluR2 (~100 kDa) and the upper band is likely a receptor dimer and frequently appears in immunoblots of mGluRs (Reid and Romano, 2001; Romano et al., 1996).

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 1