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Insulin-like Growth Factor Binding Protein-5 human
| 产品编号： | 4094035 |
| 规格： | >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder |
| 包装规格： | 25 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Insulin-like Growth Factor Binding Protein-5 human
IGFBP-5
基本信息
| MDL number | MFCD03457235 |
| NACRES | NA.32 |
| General description【一般描述】 | The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35. |
| Biochem/physiol Actions【生化/生理作用】 | IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology. IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA. |
| Analysis Note【分析说明】 | The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in NSO cells |
| Assay【测定】 | >90% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | 0.5-1.5 mg per mL ED50 |
| mol wt【分子量】 | 34 kDa by SDS-PAGE (reducing) calculated mol wt ~28 kDa |
| impurities【杂质】 | endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | P24593 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IGFBP5(3488) |
| packaging【包装】 | 25 μg in glass insert |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
