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Anti-Mitofusin-1 Antibody
| 产品编号： | 4094515 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Mitofusin-1 Antibody
Fzo homolog, Transmembrane GTPase MFN1, Mitofusion-1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Along with Mitofusin-2 (Mfn2), Mitofusin-1 (Mfn1) is a known protein mediator of mitochondrial fusion. Mitochondrial fusion regulates mitochondrial morphogensis and supports complementation between mitochondrial genomes in mammalian cells. Two Mfn1 transcripts are detected at similar levels in a variety of human tissues and are dramatically elevated in the heart. Human Mfn1 is known to be localized in the mitochondria. It is reported that point mutations in the conserved G1 and G2 region of the Mfn1 GTPase domain result in decreased formation and fragmentation of the mitochondria, respectively. |
| Specificity【特异性】 | This antibody recognizes Mitofusin-1 at the cytoplasmic domain. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Mitofusin-1. Epitope: Cytoplasmic Domain |
| Application【应用】 | Research Category Cell Structure Detect Mitofusin-1 using this Anti-Mitofusin-1 Antibody validated for use in WB. Research Sub Category Organelle & Cell Markers |
| Quality【质量】 | Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitofusin-1 in 10 µg HeLa cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control HeLa cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, mouse, human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_284941 |
| UniProt accession no.【UniProt登记号】 | Q8IWA4 |
产品说明
| Target description【目标描述】 | ~86 kDa observed. Three isoforms of Mitofusin-1 are produced by alternative splicing with molecular weights of ~42 kDa, ~71 kDa, and ~84 kDa Uncharacterized bands may appear at ~45 kDa, ~48 kDa, and ~55 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
