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p27 Protein complex, activated, 10 μg
| 产品编号： | 4094718 |
| 规格： | Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays. |
| 包装规格： | 10 μG，250 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
p27 Protein complex, activated, 10 μg
p27 kip1, Cyclin-dependent kinase inhibitor 1B, Kip1
基本信息
| eCl@ss | 32160405 |
| NACRES | NA.41 |
| General description【一般描述】 | p27 is an important regulator of cell cycle progression, involved in G1 arrest. It is a potent inhibitor of cyclin E1- and cyclin A-CDK2 complexes and a positive regulator of cyclin D-dependent kinases such as CDK4. The degradation of this protein, which is triggered by its CDK-dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Decreased levels of p27 are found in various epithelial tumours originating from lung, breast, colon, ovary, oesophagus, thyroid and prostate. Defects in the gene encoding p27 (CDKN1B) are the cause of multiple endocrine neoplasia type 4 (MEN4) an inherited cancer of the thyroid. |
| Other Notes【其他说明】 | Ubiquitination Cascade Comoponent: Substrate |
| Legal Information【法律信息】 | Purified using immobilized metal affinity chromatography. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | human |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable |
| GenBank® accession no. | BC001971 (p27) |
| NCBI accession no.【NCBI登记号】 | NM_001238 (Cyclin E1) NM_001798 |
| Gene Information | human ... CDK2(1017), CDKN1B(1027) |
产品说明
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
