MnTBAP-Calbiochem

C₄₈H₂₈ClMnN₄O₈

879.15

NA.77

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).

Cell permeable: yes
EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
Product does not compete with ATP.
Reversible: no
Primary Target
Superoxide dismutase (SOD) mimetic

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Aladag, M. A., et al. 2003. Acta Neurochir.145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (TLC)

solid

Calbiochem^®

OK to freeze
desiccated
protect from light

brown

aqueous base: soluble

ambient

−20℃

25 mg in Plastic ampoule

11 - Combustible Solids

WGK 1