Phloretin-CAS 60-82-2-Calbiochem

C₁₅H₁₄O₅

274.27

MFCD00002288

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). Activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca²⁺ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F_2α receptors linked to phospholipase C in astrocytes.

Cell permeable: yes
Target IC₅₀: 20-50 µM against protein kinase C
Product does not compete with ATP.
Reversible: no

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.

Berry, G.T., et al. 1994. Pediat. Res.35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci.5, 699.
Kitanaka, J., et al. 1993. J. Neurochem.60, 704.
Wang, X., et al. 1993. Biochem. J.290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol.59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res.50, 569.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (TLC)

solid

Calbiochem^®

OK to freeze

white

acetone: soluble
ethanol: soluble
methanol: soluble

ambient

−20℃

1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2

VGEREEWJJVICBM-UHFFFAOYSA-N

200 mg in Plastic ampoule

GHS07

Warning

H315 - H319 - H335

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 2